The mRNA-LNP lab,
from sequence to in vivo.
On-demand services, all in one lab:
- mRNA & LNP design
- Manufacturing & QC
- In vitro testing
- In vivo preclinical testing
Idea to preclinical data in as little as 6 weeks.
Build your own wet lab pipeline
mRNA design, manufacturing, LNP formulation, in vitro screening and in vivo testing, run end to end by one team.
Use the full pipeline or only the stages you need.
-
Design
Optimise your sequence & confirm manufacturing requirements
Results- Optimised mRNA sequence
- Manufacturing and QC specification
- Study design and quote
-
Build
Manufacture mRNA, formulate LNPs and run QC assays.
Results- mRNA and LNPs, ready to use
- QC report: integrity, purity, dsRNA
- LNP size, PDI and encapsulation
-
Screen
Evaluate expression and function in vitro.
Results- In vitro expression and function data
- Lead candidate selection
-
Test
Assess efficacy, safety and biodistribution in vivo.
ResultsAbout our in vivo testing →- In vivo efficacy and safety data
- Biodistribution by organ
- Full study report
Built by mRNA
scientists for
mRNA programs.
Every project adds to the platform. We protect each customer's privacy and use what we learn to improve the work we do for the next one.
Flexible by design
Use us for one stage or all four. We fit the scope to your requirements.
Speed to data
Design, synthesise, test, evaluate. All mRNA synthesis, LNP formulation and testing is done here in Australia.
One partner, full cycle
From first design to in vivo evaluation. No hand-offs between CROs, no lost context.
A well-validated LNP toolkit for your RNA.
Encapsulate your RNA in LNPs optimised for your research:
- Benchmark ionisable lipids
- Well-characterised safety profiles
- Novel formulations
- Designed for specific targets
One partner.
Fewer bottlenecks.
Most mRNA programs piece together separate suppliers, often in different countries. We do it all in one lab in Melbourne, to one high standard, and one team answers for the result.
Your sequences and your results stay yours. Use the whole pipeline, or only the stages you need.
Notes from the bench.
Guides and explainers on mRNA design, production and delivery, written by the scientists who make it every day.
dsRNA in IVT mRNA: where it comes from and how to remove it
Double-stranded RNA by-products of in vitro transcription can trigger innate immune sensors and suppress translation. We look at why they form and which purification steps actually clear them.
Read article →Cap1 vs Cap0: why the 5′ cap matters for expression
How the cap structure affects immune recognition and protein output in your cells.
Choosing an ionisable lipid: SM-102, ALC-0315, MC3 and beyond
What to weigh when you match a lipid to your payload and target tissue.
N1-methylpseudouridine, explained
Why one base modification lowers immune recognition, and when 5moU is the better choice.
Start from a product, or from a sequence.
Design, build, screen and test, in one lab
Send us a target. We design and make the mRNA, formulate the LNPs, and test them in vitro and in vivo, all in Melbourne.
- Custom mRNA, µg to mg
- LNP formulation, incl. co-formulation
- In vitro expression and function
- In vivo efficacy and biodistribution
Your sequence, made into high-quality mRNA
Designed and produced on demand, from µg to mg. Cap1 capping, M1Ψ or 5moU, dsRNA removal and full QC.
mFlame™, EverGreen™, EGFP, FLuc, NanoLuc, Cre, mCherry, PEmax
Our most popular base-modified mRNAs, ready to transfect.
Armada™ LNP Transfection Kit
A simple, pipette-compatible workflow for mRNA, siRNA, gRNA, sgRNA and pegRNA, even in hard-to-transfect cells.
Embark™ mRNA Purification Kit
Purify IVT mRNA in your own lab. Removes all major reaction contaminants, including the dsRNA most other kits leave behind.
ShipRight™ RT mRNA Shipping
Fully protects mRNA integrity at room temperature and is compatible with downstream in vitro and in vivo work.
50+ ready-made mRNAs and reagents
Gene-editing, cytokine, growth factor and transcription factor mRNAs, plus lab reagents.
Have a project in mind?
Tell us what you're working on. One of our scientists will get back to you within 48 hours.
Contact us → or email hello@messenger.bioHave a project in mind?
Email us at help@messenger.bio or use the form below.