Also available as mRNA-LNP
(To pay with a purchase order, please send your purchase order to sales@messenger.bio.)
Messenger Bio's Cre mRNA is codon optimized for high expression and offers a targeted approach to DNA modification, allowing precise deletion, inversion, or translocation of specific genetic sequences via loxP site recognition.
We developed Cre mRNA by fine-tuning the key determinants of Cre recombinase mRNA expression, including the 5’ and 3’ UTRs as well as the protein-coding region itself.
Cre mRNA includes a Cap1 structure (biologically superior to Cap0), a highly expressing 5’ UTR and highly stable 3’ UTR, a 100-nt poly(A) tail, and a codon-optimized open reading frame. Choose from unmodified or modified (N1-methylpseudouridine or 5-methoxyuridine) bases. Both types of modified bases have been shown to enhance protein expression in vitro and in vivo.
Our robust purification process removes dsRNA contaminants and other reaction components, generating highly pure mRNA that is capable of inducing very high levels of protein expression in diverse cell types, while causing minimal cellular innate immune activation (virtually undetectable).
As with all our mRNAs, this Cre mRNA comes ready-to-use in a 1 mM sodium citrate buffer (pH 6.5), which is ideal for preserving RNA stability and extending shelf-life. Just complex with your favorite transfection reagent, and you’re ready to go. Alternatively, speak to us about our ready-to-transfect LNP formulations.
If you would like to request a different amount of mRNA than what is listed on our website, or a different type of modified base, or any more information about our Cre mRNA, send us an email at hello@messenger.bio, and we’ll be happy to help.
For Research Use Only. See Terms of Sale for more.
Also available as mRNA-LNP
(To pay with a purchase order, please send your purchase order to sales@messenger.bio.)
Messenger Bio's Cre mRNA is codon optimized for high expression and offers a targeted approach to DNA modification, allowing precise deletion, inversion, or translocation of specific genetic sequences via loxP site recognition.
We developed Cre mRNA by fine-tuning the key determinants of Cre recombinase mRNA expression, including the 5’ and 3’ UTRs as well as the protein-coding region itself.
Cre mRNA includes a Cap1 structure (biologically superior to Cap0), a highly expressing 5’ UTR and highly stable 3’ UTR, a 100-nt poly(A) tail, and a codon-optimized open reading frame. Choose from unmodified or modified (N1-methylpseudouridine or 5-methoxyuridine) bases. Both types of modified bases have been shown to enhance protein expression in vitro and in vivo.
Our robust purification process removes dsRNA contaminants and other reaction components, generating highly pure mRNA that is capable of inducing very high levels of protein expression in diverse cell types, while causing minimal cellular innate immune activation (virtually undetectable).
As with all our mRNAs, this Cre mRNA comes ready-to-use in a 1 mM sodium citrate buffer (pH 6.5), which is ideal for preserving RNA stability and extending shelf-life. Just complex with your favorite transfection reagent, and you’re ready to go. Alternatively, speak to us about our ready-to-transfect LNP formulations.
If you would like to request a different amount of mRNA than what is listed on our website, or a different type of modified base, or any more information about our Cre mRNA, send us an email at hello@messenger.bio, and we’ll be happy to help.
For Research Use Only. See Terms of Sale for more.
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